Thursday, March 2, 2017

One of the formative books in my personal and intellectual development is Nikolas Rose’s Politics of Life Itself. Rose describes these as “the growing capacities to control, manage, engineer, reshape, and modulate the very vital capacities of human beings as living creatures.” Through advances in medicine, we’ve disrupted a “natural vital order” by imagining life at the molecular level, life as a set of mechanisms that can be identified, isolated, and manipulated in brand new ways. We now conceptualize individuals in new ways through a molecular, medical gaze: susceptible to illness, vulnerable to stress, immunocompromised.

Petryna’s ideas of experimentality and the growth of global pharmaceutical trials represent one of the ways these capacities manifest. This work fits quite neatly as a prologue to Biehl’s notion of pharmaceuticalization. (And no wonder; the two are married). Biehl, focusing on AIDS and ART in particular, writes about the ways that public health infrastructures are being transformed as a result of increasing numbers of pharmaceuticals. Petryna details how those get to market. A few scattered thoughts:

1. The subtitle of Rose’s book is “Biomedicine, Power, and Subjectivity in the Twenty-First Century.” If I have one critique of Petryna, it’s that she could explore more nuanced notions of power. She gained access to so many people, and yet the majority of voices in the text are those who hold (ostensibly) greater power. More patient voices would have, I think, helped to blur the dichotomy that the book predominantly treads in, especially in Poland.

2. I don't’ know if it’s because I’m in a school of public health and spend parts of the week on the medical campus, but I am constantly amazed, in reflection on these authors, how normalized this “biological citizenship” (Petryna’s earlier work) has become. Healthcare spending in the US is roughly 18% of our GDP.

And what does that get us? I find this map amazing when considering the difference between, for example, Costa Rica ($811 per person/per year in healthcare costs) and the US (8360). I’m not sure what figures correspond to pharmaceutical spending, but it’s clear that either way we and many other Western countries devote high levels of resources and attention to health.

Rose writes about the ways that psychological pharmaceuticals have changed the way we think about the self. “Individuals are prescribed them, and utilize them, in the hope of restoring themselves to a state they feel they have lost.” But what about the patients who enroll for Gaucher disease in Brazil? What about the untried CVD drugs in Poland? What are their rights to such drugs? I’m sure we’re going to be talking a lot about the profit motives behind pharmaceutical expansion (especially “me-too” drugs and drugs which treat rare conditions), but I think it’s also important to keep in mind that supply is meeting demand. How that demand is created I think Petryna only began to explore.

3. Finally, there’s plenty of overlap here with the idea of evidence-based medicine (and its limitations), which some have discussed in class. I think Petryna does a particularly good job of the explaining the development of regulatory requirements for pharmaceuticals and how statistics play a large role in getting drugs cleared – to patients’ detriment, I think Petryna would argue. Yet these are also the same requirements that help to keep patients safe.



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